Increased Serum KL-6 Levels Induced by Pulmonary Mycobacterium Avium Complex Infection in a Patient with RA-associated Lung Disease.

نویسندگان

  • Koichi Waseda
  • Kazuki Ocho
  • Kou Hasegawa
  • Kosuke Kimura
  • Masaya Iwamuro
  • Yoshihisa Hanayama
  • Eisei Kondo
  • Nobuaki Miyahara
  • Fumio Otsuka
چکیده

KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with prednisolone, chest image findings improved in association with decreased KL-6 levels. Following tapering of prednisolone, chest image findings deteriorated again as levels of KL-6 increased, suggesting recurrence of RA-ILD. Bronchoscopic examination revealed active MAC infection. Treatment of MAC infection not only improved chest image findings but also decreased KL-6 levels in serum, suggesting that KL-6 was increased by active MAC infection by itself, not by recurrence of RA-ILD. To the best of our knowledge, this is the first documentation of KL-6 elevation in serum in association with active MAC infection.

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عنوان ژورنال:
  • Acta medica Okayama

دوره 70 3  شماره 

صفحات  -

تاریخ انتشار 2016